The GLP-1 Reset: Why You’re Being Switched — and What It Means for Your Weight Loss
Bridging the Gap: Life After Semaglutide and Tirzepatide
Why the Switch?
If you’ve been using compounded semaglutide or tirzepatide for weight loss, you may have recently been told by your provider or pharmacy that it’s no longer available.
That’s because as of mid-2025:
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Compounded semaglutide and tirzepatide are no longer permitted
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They were removed from the FDA’s official drug shortage list
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Under federal law, a drug cannot be compounded once it’s available from the manufacturer and no longer in shortage
🔒 That means pharmacies must stop offering compounded versions, even if patients have tolerated them well or found them more affordable.
What Are Providers Doing Now?
To continue supporting patients, many providers and telehealth platforms (including major national groups) are now switching to:
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Liraglutide (Victoza®, Saxenda®) – Primary replacement
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Dulaglutide (Trulicity®) – Secondary option when available
These are FDA-approved GLP-1 receptor agonists and can still support weight loss — but there are important differences you need to know.
How Do These Compare?
💡 Key Takeaway:
These medications aren’t as strong — and most patients report:
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Increased appetite
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Slower weight loss
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Earlier plateaus
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More difficulty staying consistent (especially with daily injections like liraglutide)
What’s Missing? Multi-Hormonal Support
Newer medications like tirzepatide don’t just activate GLP-1 receptors — they mimic multiple hormones involved in appetite, metabolism, and blood sugar regulation.
By contrast, liraglutide and dulaglutide:
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Only activate GLP-1
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Do not support GIP or amylin pathways
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Have lower binding affinity at the GLP-1 receptor
The result?
Less hunger control, lower insulin sensitivity, and slower results.
How to Bridge the Gap: Add SLM+
SLM+ was designed specifically for patients on plain GLP-1 therapy (like liraglutide or dulaglutide) who need to optimize their results.
It contains three natural, clinically studied ingredients that work synergistically to improve metabolic performance:
🧠 SLM+ helps your GLP-1 therapy work harder — supporting the same multi-hormonal synergy that made semaglutide and tirzepatide so effective.
Real-World Results
🔍 Patients using SLM+ with plain GLP-1s experience better satiety, fewer stalls, and stronger long-term outcomes.
What To Do Now
✅ If you’re switching: Add SLM+ immediately as you begin liraglutide or dulaglutide
✅ If you’re a provider or pharmacy: Sign up for wholesale pricing, protocol support, and educational materials
✅ If you’re unsure: Read How to Transition Smoothly for a detailed plan
You’ve worked hard to get here. Don’t lose momentum. SLM+ helps ensure you keep moving forward — even after switching medications.
Medical Disclaimer: This blog is for informational purposes only and is not intended as medical advice. Always consult your healthcare provider before making any changes to your medications, supplements, or health regimen. Individual results may vary.
Pharmacy and Provider Disclaimer: STAAR LABS is not a licensed pharmacy, medical provider, or drug manufacturer. We do not dispense, prescribe, or sell prescription medications. All content is provided for informational and educational purposes only. Patients should consult their licensed healthcare provider or pharmacy before making any changes to their treatment plan.
Supplement Disclaimer: Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Research & Innovation Disclosure: STAAR LABS conducts protocol development in collaboration with licensed providers and pharmacies. Our research focuses on combining nutraceutical and pharmaceutical interventions to enhance metabolic outcomes. Weight loss projections involving SLM+ are based on early observational feedback and theoretical mechanisms, not yet published in peer-reviewed clinical trials.
