GLP-1 Alone Isn’t Enough: The Missing Link in Liraglutide and Dulaglutide Therapy

Bridging the Gap: Life After Semaglutide (Part 2)

______________________________________________________________

Why Liraglutide and Dulaglutide Alone Often Fall Short

Thousands of patients across the U.S. are now being transitioned to liraglutide or dulaglutide following the FDA’s removal of compounded semaglutide and tirzepatide from the shortage list.

While these older GLP-1 medications are still FDA-approved and widely used, they are not as effective — especially when used alone.

Here’s why.

1. Lower Receptor Potency = Lower Performance

Compared to semaglutide and tirzepatide, liraglutide and dulaglutide have significantly lower affinity for the GLP-1 receptor.

That means:

Less appetite suppression
Weaker insulin response
Earlier plateaus
Higher likelihood of weight regain

🔎 If patients notice the difference — they’re not imagining it.

2. These GLP-1s Lack Multi-Hormonal Support

Tirzepatide works so well because it activates both GLP-1 and GIP receptors, delivering broad metabolic benefits.

But liraglutide and dulaglutide only activate GLP-1, and do not support:

GIP (glucose-dependent insulinotropic polypeptide)
Amylin (key for satiety and blood sugar regulation)
Broader metabolic signaling

The result?

Slower fat loss, increased hunger, and reduced energy expenditure.

3. Patients on Plain GLP-1s Often Plateau Early

Most patients report strong initial weight loss in the first 8–12 weeks — then hit a wall. Common complaints:

“The weight stopped coming off.”
“I’m hungry again like I was before.”
“My energy crashed.”
“It’s not working like it used to.”

These symptoms are signs that your protocol isn’t metabolically complete — and that your body needs help restoring balance.

4. SLM+ Is Designed to Fill the Gap

SLM+ by STAAR LABS was created to help patients on plain GLP-1s (like liraglutide or dulaglutide) experience better outcomes.

By combining three clinically studied ingredients, SLM+ helps:

Improve insulin sensitivity
Support GIP-like signaling for fat metabolism
Enhance GLP-1 responsiveness
Stabilize post-meal glucose and energy levels

🎯 Think of SLM+ as the missing link that turns a one-dimensional GLP-1 protocol into a multi-hormonal metabolic solution.

SLM+ May Help You Regain Momentum

📈 SLM+ users report:

More consistent fat loss
Reduced cravings
Improved energy
Longer sustainability

“I was gaining back weight after semaglutide — adding SLM+ helped me stabilize and start moving in the right direction again.” — Deb

What To Do Next

🔹 If you’re a patient switching to liraglutide or dulaglutide, start SLM+ immediately to avoid stalls.

🔹 If you’re a provider or pharmacy, sign up for a wholesale account and learn about our GPS Protocols that combine prescription therapy + SLM+ for stronger outcomes.

🔹 Have questions? Contact us to request a provider guide or dosing chart.

Medical Disclaimer: This blog is for informational purposes only and is not intended as medical advice. Always consult your healthcare provider before making any changes to your medications, supplements, or health regimen. Individual results may vary.

Supplement Disclaimer: Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Research & Innovation Disclosure: STAAR LABS conducts protocol development in collaboration with licensed providers and pharmacies. Our research focuses on combining nutraceutical and pharmaceutical interventions to enhance metabolic outcomes. Weight loss projections involving SLM+ are based on early observational feedback and theoretical mechanisms, not yet published in peer-reviewed clinical trials.

Pharmacy and Provider Disclaimer: STAAR LABS is not a licensed pharmacy, medical provider, or drug manufacturer. We do not dispense, prescribe, or sell prescription medications. All content is provided for informational and educational purposes only. Patients should consult their licensed healthcare provider or pharmacy before making any changes to their treatment plan.